_{13th July, 2026}

Principal Computational Biologist
Location: Boston, MA (Hybrid)

This is an exciting opportunity to join a clinical-stage biotechnology company developing first-in-class therapies through a novel understanding of biology. Working at the forefront of drug discovery, the organisation combines cutting-edge biology with computational science to speed up the development of new treatments for patients.

We are looking for a Principal Computational Biologist to lead the companies computational biology efforts. You’ll work alongside biologists and chemists using bioinformatics to drive drug discovery decisions and influence strategy. You will lead the design, execution and interpretation of complex bioinformatics analyses across multiple therapeutic programmes.

Key Responsibilities

• Partner with scientists to design computational strategies that answer key biological questions.
• Develop and implement bioinformatics pipelines for the analysis of multi-omics datasets.
• Evaluate and introduce emerging analytical methods and technologies where appropriate.
• Analyse RNAseq, proteomics, phospho-proteomics and whole genome sequencing data.
• Integrate pathway databases, network resources and published literature to generate meaningful biological insights.
• Present complex analyses in a clear and impactful way.
• Lead bioinformatics workstreams from conception through to delivery.
• Mentor junior team members.

What we are looking for:

• PhD in Bioinformatics, Computational Biology, Genomics or a related field.
• 4 or more years of post-PhD industry experience
• Strong programming skills in Python and/or R.
• Proficiency analysing bulk RNA-seq datasets.
• Expertise in statistical analysis of transcriptomics and proteomics data, including differential expression and pathway analysis.
• Experience integrating multi-omics datasets to answer biological questions.
• Strong understanding of molecular biology and drug discovery.
• Excellent communication skills with the ability to collaborate across multidisciplinary research teams.

  
This is a highly collaborative, hands-on role offering significant ownership and the opportunity to shape computational biology capabilities within a rapidly growing biotech, which you can grow with. Apply today to be considered.
  
  
  
  
  
  
  
  
  
  
  
  
  
  










  
  
Keywords: Bioinformatics / Bioinformatician / computational biology / computational biologist / RNAseq / RNA-seq / transcriptomics / single cell / singlecell / multiomics / multi-omics / proteomics / genomics / drug discovery / biotech / biotechnology / lead / principal / leadership

 

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